全文获取类型
收费全文 | 3138篇 |
免费 | 274篇 |
国内免费 | 334篇 |
专业分类
化学 | 282篇 |
晶体学 | 2篇 |
力学 | 324篇 |
综合类 | 125篇 |
数学 | 2420篇 |
物理学 | 593篇 |
出版年
2024年 | 5篇 |
2023年 | 15篇 |
2022年 | 36篇 |
2021年 | 38篇 |
2020年 | 64篇 |
2019年 | 43篇 |
2018年 | 58篇 |
2017年 | 73篇 |
2016年 | 101篇 |
2015年 | 63篇 |
2014年 | 124篇 |
2013年 | 194篇 |
2012年 | 173篇 |
2011年 | 209篇 |
2010年 | 187篇 |
2009年 | 235篇 |
2008年 | 222篇 |
2007年 | 245篇 |
2006年 | 213篇 |
2005年 | 182篇 |
2004年 | 151篇 |
2003年 | 166篇 |
2002年 | 120篇 |
2001年 | 112篇 |
2000年 | 95篇 |
1999年 | 98篇 |
1998年 | 105篇 |
1997年 | 73篇 |
1996年 | 59篇 |
1995年 | 36篇 |
1994年 | 40篇 |
1993年 | 32篇 |
1992年 | 33篇 |
1991年 | 17篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 16篇 |
1981年 | 12篇 |
1980年 | 11篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1971年 | 1篇 |
1936年 | 2篇 |
排序方式: 共有3746条查询结果,搜索用时 15 毫秒
61.
Accurate and efficient targets extraction from blurred trace infrared images has very important meaning for latent trace evidence collection in crime scene. Based on the superstring theory, a superstring galaxy template extraction algorithm for infrared trace target is presented. First, all of the pixels are divided into three classes: target pixels, background pixels and blurred pixels. Next, the superstring template characteristics for every pixel in a blurred infrared image are calculated as the features of each pixel. Finally, a galaxy covering algorithm is proposed, target pixels and background pixels are used for training the galaxy covering domain of every galaxy classifiers, and these classifiers will divide each blurred pixel into two classes: a target pixel or a background pixel. Experimental results indicate that the superstring galaxy template algorithm can improve the target extraction rate and reduce the extraction error rate. 相似文献
62.
在化学反应流的概率密度函数(PDF)方法中,对流项和化学反应项都是封闭的,但分子扩散项必须模拟。现有的分子扩散模型都是唯象的,需要引入外加参数,并难以通过一些基本物理过程的检验。本文发展了随机映射逼近(mapping closure approximation,MCA)方法,解析地从控制方程导出一个封闭的分子扩散模型。该方法考虑两点联合概率密度函数方程,引入空间特征尺度,因此解决了以往映射封闭方法中分子扩散速率无法确定的问题。数值模拟表明该方法能用于预测标量扩散的速度,以及概率密度函数和条件平均扩散等统计量。 相似文献
63.
J. M. Soriano 《应用数学和力学(英文版)》2006,27(9):1265-1274
Sufficient conditions were given to assert that between any two Banach spaces over K, Fredholm mappings share at least one value in a specific open ball. The proof of the result is constructive and based upon continuation methods. 相似文献
64.
Nazia Noor Joachim Koll Maryam Radjabian Clarissa Abetz Volker Abetz 《Macromolecular rapid communications》2016,37(5):414-419
A double‐layer hollow fiber is fabricated where an isoporous surface of polystyrene‐block‐poly(4‐vinylpyridine) is fixed on a support layer by co‐extrusion. Due to the sulfonation of the support layer material, delamination of the two layers is suppressed without increasing the number of subsequent processing steps for isoporous composite membrane formation. Electron microscope‐energy‐dispersive X‐ray spectroscopy images unveil the existence of a high sulfur concentration in the interfacial region by which in‐process H‐bond formation between the layers is evidenced. For the very first time, our study reports a facile method to fabricate a sturdy isoporous double‐layer hollow fiber.
65.
The article considers a class of differential iterative equations with biological background. We establish some sufficient conditions for the existence of positive pseudo almost periodic solutions by applying exponential dichotomy and contraction mapping principle. The obtained results extend some known ones. 相似文献
66.
In this paper, we continue our investigation of polyharmonic mappings in the complex plane. First, we establish two Landau type theorems. We also show a three circles type theorem and an area version of the Schwarz lemma. Finally, we study Lipschitz continuity of polyharmonic mappings with respect to the distance ratio metric. 相似文献
67.
Hyeonbae Kang Hyundae Lee Mikyoung Lim 《Mathematical Methods in the Applied Sciences》2015,38(9):1847-1854
We present a new systematic method to compute the Riemann mapping from the outside of the unit disc to the outside of a simply connected domain. We derive explicit relations between the coefficients of the Riemann mapping and the generalized polarization tensors associated with the domain. Because the generalized polarization tensors can be computed numerically, we are able to compute the coefficients of the Riemann mapping using these relations. Effectiveness of the method is validated by numerical examples. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
68.
The SARS-CoV-2 virus is causing COVID-19 resulting in an ongoing pandemic with serious health, social, and economic implications. Much research is focused in repurposing or identifying new small molecules which may interact with viral or host-cell molecular targets. An important SARS-CoV-2 target is the main protease (Mpro), and the peptidomimetic α-ketoamides represent prototypical experimental inhibitors. The protease is characterised by the dimerization of two monomers each which contains the catalytic dyad defined by Cys145 and His41 residues (active site). Dimerization yields the functional homodimer. Here, our aim was to investigate small molecules, including lopinavir and ritonavir, α-ketoamide 13b, and ebselen, for their ability to interact with the Mpro. The sirtuin 1 agonist SRT1720 was also used in our analyses. Blind docking to each monomer individually indicated preferential binding of the ligands in the active site. Site-mapping of the dimeric protease indicated a highly reactive pocket in the dimerization region at the domain III apex. Blind docking consistently indicated a strong preference of ligand binding in domain III, away from the active site. Molecular dynamics simulations indicated that ligands docked both to the active site and in the dimerization region at the apex, formed relatively stable interactions. Overall, our findings do not obviate the superior potency with respect to inhibition of protease activity of covalently-linked inhibitors such as α-ketoamide 13b in the Mpro active site. Nevertheless, along with those from others, our findings highlight the importance of further characterisation of the Mpro active site and any potential allosteric sites. 相似文献
69.
Taking the chemical equilibria including acid-base equilibrium, complexation equilibrium, precipitation equilibrium and redox equilibrium as an example, the application of the mind mapping combined with problem-based learning in university chemistry teaching is introduced. 相似文献
70.
Willem Jespers Dr. Grégory Verdon Dr. Jhonny Azuaje Dr. Maria Majellaro Dr. Henrik Keränen Prof. Xerardo García-Mera Dr. Miles Congreve Dr. Francesca Deflorian Dr. Chris de Graaf Dr. Andrei Zhukov Dr. Andrew S. Doré Dr. Jonathan S. Mason Prof. Johan Åqvist Dr. Robert M. Cooke Prof. Eddy Sotelo Dr. Hugo Gutiérrez-de-Terán 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(38):16679-16686
We present a robust protocol based on iterations of free energy perturbation (FEP) calculations, chemical synthesis, biophysical mapping and X-ray crystallography to reveal the binding mode of an antagonist series to the A2A adenosine receptor (AR). Eight A2AAR binding site mutations from biophysical mapping experiments were initially analyzed with sidechain FEP simulations, performed on alternate binding modes. The results distinctively supported one binding mode, which was subsequently used to design new chromone derivatives. Their affinities for the A2AAR were experimentally determined and investigated through a cycle of ligand-FEP calculations, validating the binding orientation of the different chemical substituents proposed. Subsequent X-ray crystallography of the A2AAR with a low and a high affinity chromone derivative confirmed the predicted binding orientation. The new molecules and structures here reported were driven by free energy calculations, and provide new insights on antagonist binding to the A2AAR, an emerging target in immuno-oncology. 相似文献